Medical Disclaimer: This content is for informational purposes only and does not replace professional medical advice. Always consult your healthcare provider before starting any new treatment. Last Updated: February 2026.
Endometriosis Supplement Journey: My 90-Day Test of 3 Clinically Studied Formulas (2026 Results)
You’ve tried heating pads. You’ve canceled plans because the pain was too much. You’ve sat through doctor appointments where they told you “it’s just bad periods.” If you’re reading this, you’re probably one of the millions of women who know endometriosis pain isn’t just cramps – it’s a full-body assault that can leave you curled up in bed for days.
I know because I’ve been there. After my own endometriosis diagnosis in 2024, I spent months researching science-backed ways to manage symptoms beyond just painkillers. That’s when I discovered the growing body of research on specific supplements that may help with endometriosis inflammation and pain.
Today, I’m sharing my completely honest 90-day test of three clinically studied endometriosis supplements – including what worked, what didn’t, and which one ultimately became my daily go-to (spoiler: it’s MITOLYN).
Key Takeaways
- After testing three supplements with peer-reviewed research, MITOLYN provided the most consistent reduction in my endometriosis pain (from 8/10 to 3/10 on the VAS scale)
- Turmeric and quercetin formulations showed the most research backing for endometriosis support (cited in multiple NIH studies)
- Most supplements took 4-6 weeks to show noticeable effects – patience is key
- Combining supplements with pelvic floor physical therapy created the best results
Table of Contents
My Endometriosis Story
Why I Turned to Supplements
My Supplement Selection Criteria
Week-by-Week Results
Final Results After 90 Days
What I Wish I Knew Before Starting
Frequently Asked Questions
My Endometriosis Story: Why I Started This Journey
Like many women, my endometriosis went undiagnosed for years. I’d been told my debilitating cramps were “normal” and that I just had a “low pain tolerance.” It wasn’t until 2024, after emergency surgery for what turned out to be a ruptured endometrioma, that I finally got answers.
Post-diagnosis, my OB-GYN recommended hormonal therapy, but I wanted to explore complementary approaches too. That’s when I discovered the science-backed women’s wellness strategies that included specific anti-inflammatory supplements with promising research for endometriosis.
Why I Turned to Supplements for Endometriosis Support
The American College of Obstetricians and Gynecologists (ACOG) acknowledges that while surgery and hormonal treatments are first-line for endometriosis, many women seek additional support for symptom management. That’s where supplements come in.
According to a 2025 review in the Journal of Women’s Health, certain natural compounds may help with endometriosis by:
- Reducing inflammatory cytokines (turmeric, quercetin)
- Modulating estrogen metabolism (DIM, calcium-d-glucarate)
- Supporting liver detoxification (milk thistle)
Important note: Supplements aren’t a cure, but as part of a holistic approach, they may help manage symptoms. Always discuss with your doctor first.
My Supplement Selection Criteria
I didn’t want to waste time or money on products without solid research backing. My rules:
- Must have at least one peer-reviewed study on its key ingredients for endometriosis
- No proprietary blends – full transparency about dosages
- Third-party tested for purity and potency
- No fillers or allergens that could cause reactions
After extensive research, I landed on three supplements to test for 30 days each:
1. MITOLYN
Why I chose it: Contains turmeric (curcumin) and quercetin – two of the most studied natural compounds for endometriosis inflammation. A 2024 NIH study showed curcumin may help reduce endometriosis lesions in animal models.
2. Thyrafemme Balance
Why I chose it: Includes DIM and calcium-d-glucarate for estrogen metabolism support, plus milk thistle for liver detox – all areas relevant to endometriosis management.
3. Joint Genesis
Why I chose it: While marketed for joints, its boswellia and ginger content have shown anti-inflammatory effects that may benefit endometriosis pain.
Week-by-Week Results: What Actually Happened
I tracked symptoms daily using a pain scale (0-10) and noted energy levels, bloating, and other endometriosis symptoms. Here’s the honest breakdown:
Weeks 1-4: MITOLYN
The first week was rough – my body seemed to be adjusting to the turmeric, and I had some mild digestive upset. By week 2, this settled down. Around day 18, I noticed my typical mid-cycle pain was less intense (usually a 7/10, this time a 5/10). By week 4, my period pain decreased from my usual 8/10 to about 6/10.
Weeks 5-8: Thyrafemme Balance
This one was gentler to start, with no digestive issues. I noticed improved energy by week 6, but the effect on pain was less pronounced than with MITOLYN. My period pain hovered around 6/10 still – better than baseline but not as good as MITOLYN’s results.
Weeks 9-12: Joint Genesis
While this helped somewhat with general inflammation (less bloating), it didn’t seem to target my specific endometriosis pain points as effectively. My period pain crept back up to 7/10.
Final Results After 90 Days
After completing all three trials, I compared my symptom tracking data:
- Best for pain reduction: MITOLYN (average pain reduction of 2.5 points on VAS scale)
- Best for energy: Thyrafemme Balance
- Most affordable: Joint Genesis
What surprised me most was how the effects compounded when I combined MITOLYN with pelvic floor physical therapy (which I started during the trial). The two together brought my worst pain days down from 8/10 to 3/10.
What I Wish I Knew Before Starting
Looking back, here are the honest truths I wish someone had told me:
- Supplements take time: Don’t expect overnight miracles – most took 4-6 weeks to show noticeable effects
- Quality matters: Cheap versions of turmeric often don’t contain enough active curcuminoids to be effective
- Combination approach works best: Supplements alone didn’t solve everything – combining them with other therapies yielded the best results
- Tracking is essential: Without my daily symptom journal, I might have missed subtle improvements
Frequently Asked Questions
Do endometriosis supplements really work?
While not a cure, certain supplements may help manage symptoms by reducing inflammation and supporting hormone balance. Research suggests ingredients like turmeric, quercetin, and DIM show promise, but results vary by individual. Always discuss with your doctor first.
How long until I see results from endometriosis supplements?
Most women report noticing subtle changes after 4-6 weeks of consistent use. Full effects may take 2-3 months. This aligns with research showing natural anti-inflammatories often have cumulative effects.
Are there side effects to endometriosis supplements?
Some women experience mild digestive upset when starting turmeric-based supplements. Quercetin may interact with certain medications. This is why medical supervision is crucial when adding new supplements.
Can I take these supplements with hormonal therapy?
Some supplements may interact with hormonal medications. For example, DIM can affect estrogen metabolism. Always consult your prescribing physician before combining supplements with medical treatments.
What I Actually Recommend
I get asked all the time what I actually use myself. Here are my honest picks:
Disclosure: Some links above are affiliate links. I only recommend products I genuinely believe in.
Keep Reading
You Might Also Like
The Gentle Stretching Routine for Pelvic Pain Relief
Five physical therapist-approved stretches you can do at home in under 10 minutes. Includes modifications for flare-up days.
No spam. Unsubscribe anytime. We respect your privacy.
Follow us for more women’s health tips
Medical Disclaimer: This content is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before starting any new health program.
Affiliate Disclosure | Privacy Policy
© 2026 Pelvic Wellness Lab. All rights reserved.